Hi 👋 I’m Sonja I have late dx Bipolar 1 & Borderline Personality Disorder both in remission by natural & lifestyle plus very very late dx/very recent Inattentive ADHD & Autism, (History of PTSD/cPTSD/GAD) Dx at 49 with Bipolar & BPD at 52 & #AuDHD just this year! All my belated diagnoses have helped me as maps to manage this extreme combination of conditions. Never medicated, never hospitalised, my blogs contain a distillation of the natural means i’ve found useful to date. This is a new blog as I feel like I’m a new person now that I’ve finally got all the pieces I need to make sense out of my broken/different physiology, nervous system & psychology.

Thursday, June 8, 2023

L-Glutamine & the Gut-Brain Connection

 https://www.sciencedirect.com/science/article/pii/S2213453021000112

I put my daughter on L-Glutamine for her Fibromyalgia plus cPTSD.

Here is the abstract of the above research article

Recent research has shown that the amino acid glutamine can positively affect gut health by supporting the gut microbiome, gut mucosal wall integrity, and by modulating inflammatory responses. As modulated by the vagus nerve, via the enteric nervous system, the gut-brain connection can impact the brain's neurochemical environment. Poor gut health can disrupt the balance of neurotransmitters, which can result in neuropsychiatric based conditions such as depression. Glutamine supplementation may provide significant adjunctive nutritional support in cases of depression by promoting proper gut health and function.”

Really there is basically no one who’s gut wall integrity has not been damaged to a greater or lesser extent by modern commercial wheat with its hyper hybridised too large protein molecules so this is a general health conversation for all imo. This fact alone may in & of itself account somewhat for the extraordinary rates of auto-immune & mental illness we see in children & teens. 🤷‍♀️

I’m sensitive to ordinary gluten, it makes me super tired & very grumpy but I find I can eat non-commercial sour dough bread & be fine thanks to the gluten softening/digesting capacity of the natural bacteria.

https://pubmed.ncbi.nlm.nih.gov/32224923/

Here’s a recent research article suggesting that Glutamine supplementation protects the brain from damaging affects of chronic stress.

https://pubmed.ncbi.nlm.nih.gov/30266598/

And here is one about Glutamine as Glutamate precursor = Anti-Depressant affect.

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